In the past few years, significant progress has been made in pinpointing the neurons exhibiting earliest hyperexcitability for various neurodegenerative disorders:
- Alzheimer's disease. The hyperexcitability resulting from BDNF deficiency and other risk factors (Paper 4)
could originate in either the cholecystokinin-positive interneurons (CCK cells) or the pyramidal neurons directly modulated by the parvalbumin-positive interneurons
(PV cells) in the lateral entorhinal cortex (LEC).
- Frontotemporal dementia. The neurons exhibiting earliest hyperexcitability could be the CCK cells and/or PV cell-modulated pyramidal neurons in the anterior cingulate cortex.
- Amyotrophic lateral sclerosis. The somatostatin-positive interneurons (SOM cells) and/or PV cell-modulated pyramidal neurons in the motor cortex could exhibit the earliest hyperexcitability.
- Parkinson's disease. Hyperexcitability could originate in the projection neurons of subthalamic nucleus.
Old PDF Versions