Geon Neurodegeneration:
The Neurons Exhibiting Earliest Hyperexcitability



In the past few years, significant progress has been made in pinpointing the neurons exhibiting earliest hyperexcitability for various neurodegenerative disorders:

  • Alzheimer's disease. The hyperexcitability resulting from BDNF deficiency and other risk factors (Paper 4) could originate in either the cholecystokinin-positive interneurons (CCK cells) or the pyramidal neurons directly modulated by the parvalbumin-positive interneurons (PV cells) in the lateral entorhinal cortex (LEC).
  • Frontotemporal dementia. The neurons exhibiting earliest hyperexcitability could be the CCK cells and/or PV cell-modulated pyramidal neurons in the anterior cingulate cortex.
  • Amyotrophic lateral sclerosis. The somatostatin-positive interneurons (SOM cells) and/or PV cell-modulated pyramidal neurons in the motor cortex could exhibit the earliest hyperexcitability.
  • Parkinson's disease. Hyperexcitability could originate in the projection neurons of subthalamic nucleus.


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