Geon mTOR, Tau and Neurodegeneration Papers



The mechanistic target of rapamycin (mTOR) is a protein kinase which, upon activation, triggers the synthesis of proteins, including the Tau protein. Hyperactive mTOR, thus Tau over-production, has been demonstrated to increase the risk of Alzheimer's disease and other neurodegenerative disorders. As discussed in Paper 2, excessive Tau proteins (especially the 4-repeat isoform) can cause hyperexcitability. Therefore, hyperactive mTOR should promote hyperexcitability. This novel mechanism is now well established. Since hyperexcitability is associated with neurodegeneration, the link among mTOR, Tau, hyperexcitability and neurodegeneration provides further evidence that neurodegeneration originates from hyperexcitability.


Read Online Download PDF