Geon We Are Born to Forget: AMPAR Endocytosis Memory

 

The spine is a very dynamic structure. It changes constantly even in the absence of presynaptic stimulation. AMPARs are continuously cycled into and out of the postsynaptic membrane through a constitutive (stimulation-independent) pathway (Anggono and Huganir , 2012). Although LTP stimuli favor AMPAR incorporation into the membrane, the effect may not last long. Within three hours, the memory trace will be erased unless further processes that can maintain LTP are induced.

Image

Figure 4-1. The memory trace, increase of AMPARs at the postsynaptic membrane, may be erased by the constitutive endocytosis which removes AMPARs from the postsynaptic membrane.

 

Author: Frank Lee
First Published: April 16, 2013